THE PROCESS OF WOUND HEALING
Biomaterial implantation is widely used for the healing of wounds in the body. After implantation, two processes start, namely inflammation and wound healing within the body. The wounds recover as a result of complex dynamic processes consisting of a series of stages. The first stage of wound healing, which lasts between 1 to 5 days, is the stage involving the inflammatory response that induces flow of tissue fluids to the wound site, an increase of blood supply, cell and fibroblast proliferation. Second stage, which lasts between 5 and 14 days, is the stage where fibroblastic activity takes place, fibrin&fibronectin formation occur in the wound, collagen formation and deposition is increased, and that wound closure (or narrowing/contraction) begins. The second stage is associated with the third stage after day 14, when the rearrangement and maturation of the fibrous connective tissue of the collagen fibers with cross-linking is observed. In cases where infection, edema (swelling) or fluid discharge is minimal, recovery occurs successfully. Mechanical effects and infection are the main causes of complications in wound healing. In order to avoid such complications, the selection of biomaterials based on mechanical properties should be done attentively and the products should be sterile.